Open AccessDutch Hypothesis and British Hypothesis in Bronchial Asthma and Chronic Obstructive Pulmonary Disease (COPD)
Author(s) -
Imaoka Haruki,
Suetomo Masashi,
Hoshino Tomoaki
Publication year - 2016
Publication title -
journal of general and family medicine
Language(s) - English
Resource type - Journals
ISSN - 2189-7948
DOI - 10.14442/jgfm.17.4_272
Subject(s) - medicine , copd , asthma , pulmonary disease , bronchial hyperresponsiveness , airway , airway hyperresponsiveness , inflammation , overlap syndrome , respiratory disease , immunology , lung , anesthesia
Bronchial asthma and chronic obstructive pulmonary disease (COPD) are obstructive pulmonary diseases with airway inflammation. Both diseases have similar pathologies such as airflow limitation, inflammation and airway hyperresponsiveness. These findings provide molecular levels molecular support for both points of view in the British/Dutch hypothesis controversy regarding the relationship between bronchial asthma and COPD. Both diseases are often complicated, and a new concept such as Asthma COPD Overlap Syndrome (ACOS) is proposed.