Open AccessAutoimmune Hemolytic Anemia Associated with Primary Biliary Cirrhosis
Author(s) -
Omata Fumio,
Sato Shinkichi,
Tokuda Yasuharu,
Takahashi Osamu,
Fukui Tsuguya
Publication year - 2008
Publication title -
general medicine
Language(s) - English
Resource type - Journals
eISSN - 1883-6011
pISSN - 1346-0072
DOI - 10.14442/general.9.65
Subject(s) - primary biliary cirrhosis , ursodeoxycholic acid , autoimmune hemolytic anemia , medicine , splenectomy , gastroenterology , alkaline phosphatase , hemolytic anemia , immunology , anemia , antibody , spleen , chemistry , enzyme , biochemistry
Both primary biliary cirrhosis (PBC) and autoimmune hemolytic anemia (AIHA) are uncommon diseases. Immunological dysregulation is suggested as a causative factor for both diseases. We report a 77‐year‐old woman who suffered from warm type AIHA complicated by PBC. Her direct antiglobulin test was positive for IgG, and negative for C3. Both anti‐mitochondrial antibody and its M2 component were detected. Both alkaline phosphatase (Alp) and IgM were elevated in the serum. She was initially treated with steroids for 8 months. Her steroids were discontinued when she underwent a laparoscopic splenectomy. Ursodeoxycholic acid was discontinued due to an allergic skin reaction. Her Alp improved with bezafibrate.