Open AccessChronically Elevated Myeloperoxidase Antineutrophil Cytoplasmic Antibody Levels in an Asymptomatic 91‐year‐old Patient
Author(s) -
Maeda Sayako,
Yabuuchi Junko,
Ono Shinya,
Makiishi Tetsuya,
Hirose Kunihiko
Publication year - 2014
Publication title -
general medicine
Language(s) - English
Resource type - Journals
eISSN - 1883-6011
pISSN - 1346-0072
DOI - 10.14442/general.15.59
Subject(s) - medicine , anti neutrophil cytoplasmic antibody , myeloperoxidase , asymptomatic , hemodialysis , microscopic polyangiitis , vasculitis , allopurinol , gastroenterology , acute kidney injury , immunology , disease , inflammation
Myeloperoxidase antineutrophil cytoplasmic antibody (MPO‐ANCA) associated glomerulonephritis is commonly diagnosed in elderly patients with acute kidney injury (AKI). Prompt diagnosis and rapid initiation of appropriate therapy are essential to avoid the development of ANCA‐associated vasculitis, which can be a life‐ and organ‐threatening disease. We report a rare case of a 91‐year‐old male with a high MPO‐ANCA titer, who took allopurinol, and showed no symptoms for >20 months, following which sudden AKI and severe bronchial asthma necessitated hemodialysis and steroid administration. Chronically elevated ANCA titers should be examined for causes and followed up to limit the risk of subsequent disease development.