Helicobacter pylori Infection and High‐density Lipoprotein Cholesterol in Japanese Women: the JMS Cohort Study

Background Helicobacter pylori ( H. pylori ) infection has been reported to be associated with cardiovascular risk factors by inducing chronic low‐grade inflammation and by influencing endocrine and metabolic systems, as well as the immunological response evoked by the host. This study investigated the association between H. pylori infection and high density lipoprotein cholesterol (HDL‐C) in Japanese subjects. Methods The study subjects were 2,632 (1,061 men and 1,571 women) living in rural areas in Japan. We checked H. pylori serum immunoglobulin G (IgG), HDL‐C and other cardiovascular risk factors in 1999. Results The overall prevalence of H. pylori seropositivity was 53.5% and increased with age. The prevalence was higher among men (58.3%) than women (50.3%). H. pylori seropositive women were more associated with decreased HDL‐C than seronegative subjects (58.1±13.6 vs. 60.5±14.7, p<0.01). Multiple linear regression analysis with H. pylori seropositivity, age, body mass index (BMI), fibrinogen, blood glucose, and smoking and alcohol habits demonstrated that H. pylori seropositivity was a significant predictor of decreased HDL‐C in women. In addition, there was a linear decrease in HDL‐C with increments in the value of H. pylori antibody titer as a continuous variable in women. This association remained in H. pylori seropositive women aged ≥50 years. Moreover, H. pylori seropositive women with BMI <22 were associated with decreased HDL‐C, whereas the association was not significant in women with BMI ≥22. Conclusions We show that H. pylori seropositivity is associated with decreased HDL‐C, especially in women with a lower BMI in rural areas of Japan.