Open AccessEvaluation of Acute Toxicity of Some Medicinal Plants and their Combination in Albino Mice
Author(s) -
Tanuj Joshi,
Vijay Juyal
Publication year - 2021
Publication title -
defence life science journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 2456-379X
pISSN - 2456-0537
DOI - 10.14429/dlsj.6.16578
Subject(s) - toxicity , acute toxicity , medicinal plants , traditional medicine , toxicology , medicine , biology
Medicinal plants find use across different cultures in the world. People have derived numerous benefits by using various plants for centuries. Herbal drugs are supposed to be safe, but there are chances these might cause toxicity and other complications. Thus toxicity studies are essential for a medicinal plant before being used in humans. The present research revolves around studying the acute toxicity of Ocimum kilimandscharicum, Thymus serpyllum, Spilanthes acmella and their combination in equal ratio (COMB). For preparing the combination of extracts, the ethanolic extracts of the three plants were combined in equal amounts and administered to the animals. The acute toxicity study was carried out according to OECD (The Organisation for Economic Co-operation and Development) guideline 423 for acute toxicity. The animals were divided into four groups each containing three animals each. These groups were respectively administered ethanolic extract of O. kilimandscharicum, T. serpyllum, S. acmella and COMB in a dose of 2000 mg/kg. The animals were observed for signs of toxicity and mortality at durations specified by OECD. The results demonstrated that extracts of the three medicinal plants used in the study and their combination were found to be safe up to 2000 mg/kg.