Open AccessDevelopment and Standardisation of a Method for Inflicting Frostbite Injury in Rats and Formulation of Essential Oil in Treatment of Frostbite
Author(s) -
Kumud Joshi,
Danswrang Goyary,
Bhaskar Mazumder,
Sumit Kishor,
Prasenjit Dey,
Yangchen Doma Bhutia,
Sanjeev Karmakar,
Pronobesh Chattopadhyay,
Sanjai K. Dwivedi
Publication year - 2020
Publication title -
defence life science journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 2456-379X
pISSN - 2456-0537
DOI - 10.14429/dlsj.5.15606
Subject(s) - frostbite , medicine , dermatology , surgery
Frostbite is a cold induced injury which occurs due to exposure of a particular site of body to sub-zero temperature. One of the primary reasons for lack of proper studies about the underlying mechanism of frostbite injury is due to non-availability of any reliable animal model and method for inflicting frostbite. In our current research, a device was designed and standardised to inflict frostbite wound in wistar rat. A formulation comprising different combination of essential oils was also developed and its activity was assessed and found effective in the treatment of frostbite wound.