Open AccessLiver and Renal Cell Damage Following Excess Bee Honey Consumption in Male Wistar Rat
Author(s) -
A Agbatutu,
Jerome Ndudi Asiwe,
Olusegun G. Adebayo
Publication year - 2022
Publication title -
biology, medicine and natural product chemistry/biology, medicine, and natural product chemistry
Language(s) - English
Resource type - Journals
eISSN - 2540-9328
pISSN - 2089-6514
DOI - 10.14421/biomedich.2022.111.35-43
Subject(s) - creatinine , kidney , bilirubin , histology , lymphocyte , medicine , physiology , urea , necrosis , renal function , biology , endocrinology , biochemistry
Honey is a widely used natural product with several health benefits. However, there is paucity of information on its excessive usage. The present study investigated the effect of excess honey consumption on hepato-renal functions in male wistar rats. Twenty-eight adult male Wistar rats were selected into four groups (n=7) and treated with distilled water (control) and 1ml, 2ml and 3ml of honey respectively for 5 weeks. Thereafter, the animals were euthanised and blood as well as kidney and liver were collected for further studies. There was a significant increase in Creatinine, Bilirubin, Urea AST, ALP, total protein as well as a significant decrease in RBC, WBC, haemoglobin, lymphocyte and PCV. Histology of the liver and kidney revealed a significant degeneration and necrosis in a dose dependent manner. This study suggest that excess honey consumption causes liver and renal cellular damage as well as haematological alterations.