Open AccessTissue distribution of sulphadimidine sodium in non-starved and starved grower turkeys (meleagris gallopavo)
Author(s) -
Joseph Agbo,
Saganuwan Alhaji Saganuwan,
Patrick Azubuike
Publication year - 2016
Publication title -
international journal of pharmacology and toxicology
Language(s) - English
Resource type - Journals
ISSN - 2310-2985
DOI - 10.14419/ijpt.v4i2.6513
Subject(s) - meleagris gallopavo , withdrawal time , spleen , body weight , health hazard , veterinary drug , zoology , biology , veterinary medicine , medicine , chemistry , endocrinology , colorectal cancer , colonoscopy , chromatography , cancer , environmental health
Background: The use of veterinary drugs in food-producing animals has potential to generate residues in edible tissues and posses health hazard to consumers especially when the withdrawal period is not observed.Objectives: The study was conducted to determine the tissue residue and withdrawal period of sulphadimidine in non-starved and starved grower turkeys following a single intramuscular administration.Methods: Forty two turkeys of both sexes and 12 weeks old weighing 1.57±0.2 kg were divided into two groups of twenty one each. One group was administered a single intramuscular dose of sulphadimidine sodium (100mg/kg body weight). The other group was kept off-feed for 48 hours before drug administration. Three turkeys each were sacrificed from the starved and non-starved group and two grammes (2g) of tissue sample were harvested from selected tissues.Results: The results showed that the drug residues persisted in all the tissues of turkeys sampled for up to thirty (30) days after drug administration. The starved turkeys maintained consistently higher concentrations of the drug in the tissues than fed ones. Sulphadimidine residue was significantly increased (p 0.2 ppm is unsafe for human consumption.