Open AccessPreparation, characterization and featuring of an inclusion complex of nerol with β-cyclodextrin
Author(s) -
Mayara Ladeira Coêlho,
Herlane da Silva,
Muhammad Saiful Islam,
Vicente Galber Freitas Viana,
Ana A.C. Melo-Cavalcante
Publication year - 2017
Publication title -
international journal of medicine
Language(s) - English
Resource type - Journals
ISSN - 2309-1622
DOI - 10.14419/ijm.v5i2.7933
Subject(s) - nerol , chemistry , solubility , cyclodextrin , organic chemistry , molecule , aqueous solution , bioavailability , fourier transform infrared spectroscopy , chromatography , chemical engineering , geraniol , bioinformatics , essential oil , biology , engineering
Nerol is an acyclic type monoterpene with important biological activities. However, the low solubility in aqueous media is a limiting factor for its user. Cyclodextrins have been widely used in order to improve the solubility, stability and bioavailability of nonpolar molecules through the formation of inclusion complexes. Thus, the present study consists in the development of nerol inclusion complex in combination with the β-cyclodextrin (β-CD) followed by characterizing by thermal analysis and spectrophotometric absorption in the infrared (FTIR). The results suggest a complexation of nerol with β-CD having detours and changed the intensity of various bands. The thermo gravimetric curve of CI found to indicate an output of solvating water molecules from the complex cavity formed for replacement of drug molecules probably included. Thus, it is concluded a possibility to obtain inclusion complexes of nerol monoterpene with β-CD, which will increase its solubility and facilitate delivery process.