Open AccessSpectral characterization, microbial activities and toxicity study of some newly synthesized hydrazone derivatives
Author(s) -
N. Kalaiarasi,
S. Manivarman
Publication year - 2017
Publication title -
international journal of advanced chemistry
Language(s) - English
Resource type - Journals
ISSN - 2310-2977
DOI - 10.14419/ijac.v5i2.7739
Subject(s) - hydrazone , semicarbazide , chemistry , hydrazine (antidepressant) , thiobarbituric acid , antifungal , proton nmr , carbon 13 nmr , toxicity , organic chemistry , combinatorial chemistry , nuclear chemistry , biochemistry , antioxidant , microbiology and biotechnology , biology , lipid peroxidation
Hydrazone derivatives of 2-Thioxodihyropyrimidine-2-dione were synthesized by addition of thiobarbituric acid with phenyl hydrazine, dinitrophenyl hydrazine, semicarbazide, thiosemicarbazide and benzohydrazide respectively. Structures of these synthesized compounds are characterized by means of UV, IR, Proton-NMR, Carbon- NMR. Finally the hydrazone derivatives synthesized are screened for biological activities namely antibacterial and antifungal activities. Also in addition the toxicity studies of the compounds are also performed.