Open AccessPeripheral nervous system involvement in systemic amyloidosis
Author(s) -
E. I. Safiulina,
O. E. Zinovyeva,
В. В. Рамеев,
L. V. Kozlovskaya-Lysenko
Publication year - 2018
Publication title -
nevrologiâ, nejropsihiatriâ, psihosomatika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.157
H-Index - 9
eISSN - 2310-1342
pISSN - 2074-2711
DOI - 10.14412/2074-2711-2018-3-12-18
Subject(s) - mononeuropathy , amyloidosis , medicine , polyneuropathy , peripheral nervous system , pathology , primary systemic amyloidosis , nervous system , autonomic nervous system , amyloid (mycology) , systemic disease , pathological , peripheral neuropathy , al amyloidosis , myopathy , peripheral , central nervous system , disease , immunology , endocrinology , diabetes mellitus , heart rate , antibody , psychiatry , blood pressure , immunoglobulin light chain
Peripheral nervous system involvement may be a main manifestation of systemic amyloidosis or occur in the later stages of the disease in the presence of multiple organ pathology. Focal, multiple mononeuropathy, radiculopathy, polyneuropathy, autonomic nervous system dysfunction, and myopathy develop depending on the localization of amyloid deposits in the peripheral nervous system. The most characteristic symptom in systemic amyloidosis is sensorimotor polyneuropathy accompanied in most cases by the involvement of autonomic nerve fibers in the pathological process. In cases of systemic amyloidosis, peripheral nervous system involvement is progressive, leading to disability, which makes the early diagnosis of the disease and its neurological manifestations and subsequent pathogenetic therapy relevant.