Open AccessAvascular necrosis in systemic lupus erythematosus: total hip replacement in a patient with mutation in clotting factor V (Leiden) gene, clinical observation
Author(s) -
F. A. Cheldieva,
И. Г. Кушнарева,
В. В. Бабак,
А. Э. Храмов,
Т. М. Решетняк
Publication year - 2021
Publication title -
sovremennaâ revmatologiâ
Language(s) - English
Resource type - Journals
eISSN - 2310-158X
pISSN - 1996-7012
DOI - 10.14412/1996-7012-2021-2-69-76
Subject(s) - avascular necrosis , medicine , clotting factor , factor v leiden , mutation , coagulation , systemic lupus , factor v , immunology , gene mutation , thrombophilia , gene , gastroenterology , surgery , genetics , thrombosis , biology , venous thrombosis , disease , femoral head
The article provides a description of the systemic lupus erythematosus patient with multiple avascular bone necrosis (ABN), homozygous mutation in clotting factor V (Leiden) gene, who successfully underwent the total hip replacement. The role of high doses of glucocorticoids and coagulation disorders, in particular the homozygous mutation in factor V (Leiden) gene, in the development of ABN is discussed.