Open AccessCurrent approaches to osteoarthritis phenotyping
Author(s) -
А. М. Лила,
Л. И. Алексеева,
K. Telyshev
Publication year - 2019
Publication title -
sovremennaâ revmatologiâ
Language(s) - English
Resource type - Journals
eISSN - 2310-158X
pISSN - 1996-7012
DOI - 10.14412/1996-7012-2019-2-4-8
Subject(s) - osteoarthritis , disease , magnetic resonance imaging , comorbidity , medicine , depression (economics) , race (biology) , bioinformatics , physical medicine and rehabilitation , pathology , alternative medicine , radiology , biology , botany , economics , macroeconomics
Osteoarthritis (OA) is currently considered as a heterogeneous disease that can be represented by different subtypes. It is the study of OA phenotypes that is one of the strategic areas for the development of researches on this nosological entity, which will further allow a personified approach to patient therapy and ensure the rational use of financial resources of health care. The paper describes in detail the current researches on this issue. It discusses attempts to identify different OA types according to demographic data (age, race, gender, etc.), comorbidity (including depression), nature of pain (intensity, pathophysiological mechanisms of its development), biochemical markers, genetic and biomechanical predictors, hormonal status in patients, and structural changes detected by ultrasound, magnetic resonance imaging, and computed tomography, etc.