Open AccessDevelopment of the doctrine of auto-inflammatory diseases in the XXI century
Author(s) -
Е. С. Фёдоров,
С. О. Салугина,
Н. Н. Кузьмина
Publication year - 2019
Publication title -
naučno-praktičeskaâ revmatologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.137
H-Index - 9
eISSN - 1995-4492
pISSN - 1995-4484
DOI - 10.14412/1995-4484-2018-5-18
Subject(s) - doctrine , immunology , medicine , dominance (genetics) , intensive care medicine , biology , political science , genetics , law , gene
The article presents the development of the doctrine of autoinflammatory diseases (AID) in the last decade. Data on interleukin 1, inflammasomes and their role in the development of AID are presented. The paper also contains the data about interferonopathies and, in particular, proteasomal illnesses as a new class of hereditary autoinflammatory diseases. Variety of AID variants, including diseases with the dominance of one system damage (skin, intestines, bones) is shown. Advances in the AID diagnosis and course assessment of are discussed. Relationship of the AID with the problems of fundamental and clinical rheumatology is demonstrated.