Open AccessEFECTO DE UN SURFACTANTE NO IONICO EN LA PERMEABILIDAD DE BUTORFANOL A TRAVES DE MUCOSA NASAL EQUINA
Author(s) -
María Inés Velloso
Publication year - 2021
Publication title -
fave. sección ciencias veterinarias
Language(s) - English
Resource type - Journals
eISSN - 2362-5589
pISSN - 1666-938X
DOI - 10.14409/favecv.v19isuplemento.10945
Subject(s) - butorphanol , respiratory tract , mucous membrane of nose , pulmonary surfactant , nasal administration , respiratory system , pharmacology , chemistry , medicine , immunology , biochemistry
Implementation of intranasal administration for the delivery of drugs with site of action into the central nervous system, such as butorphanol, became a potential choice in equine medicine. In this study, using Franz-diffusion cells the in vitro permeation rate through respiratory and olfactory equine nasal mucosa of two butorphanol formulations was estimated and compared. Both formulations had the same composition, was the exception for formulation 2, that contained 2, 5 x 10 -4 M of a non-ionic surfactant (tween 80). Butorphanol administered dose was 24, 4 mg/cm2. Plots of the cumulative amounts of butorphanol against time were constructed, where maximum flux values at the steady state (Jss), apparent permeability coefficients (Kp) and lag-time (tlag) were estimated. The Jss and Kp show that permeation of butorphanol through olfactory mucosa is different than respiratory mucosa. Moreover, Jss for formulation 2 was higher than formulation 1 in both anatomical areas, probably for the effect of the surfactant. The present results are promising to carry on with the development of formulation of butorphanol for intranasal administration.