Open AccessDifferential diagnosis of morphological forms of congenital hyperinsulinism using [18F]-DOPA PET/CT
Author(s) -
Diliara Gubaeva,
Губаева Диляра Наилевна,
Maria Melikyan,
Меликян Мария Арменаковна,
Д. В. Рыжкова,
Рыжкова Дарья Викторовна,
Lubov Mitrofanova,
Митрофанова Любовь Борисовна,
И. Л. Никитина,
Никитина Ирина Леоровна
Publication year - 2018
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl9726
Subject(s) - differential diagnosis , congenital hyperinsulinism , medicine , radiology , positron emission tomography , pancreas , gold standard (test) , nuclear medicine , diabetes mellitus , hyperinsulinism , pathology , endocrinology , insulin resistance
Congenital hyperinsulinism (CHI) is caused by insulin hyperproduction by β-pancreatic cells. CHI is associated with high risk of complications of chronic hypoglycemia, and therefore timely diagnosis of the disease and immediate initiation of therapy is a top-priority task. The choice of treatment tactics largely depends on the morphological form of the disease. Morphological form cannot be established based on clinical and laboratory presentation of the disease, ultrasound, MRI, computed and positron emission tomography (PET) with [18F]-fluorodeoxyglucose. Calcium stimulation test and percutaneous transhepatic blood sampling from the portal vein were previously used for differential diagnosis, but the results provided by these invasive studies are imprecise. At present, preoperative differential diagnosis of diffuse and focal forms of CHI is based on the data of genetic testing and radionuclide diagnosis ([18F]-DOPA PET). The article presents the first results of the use of [18F]-DOPA PET in CHI patients in the Russian Federation. Radionuclide study was performed in 17 patients with pharmacoresistant CHI followed by comparative analysis of the results of 18F-FDG PET/CT and histological picture of intraoperative pancreatic tissue samples, which is known as the gold standard for the differential diagnosis of HI histological forms.