Open AccessDifferential and diagnostic, predictive and therapeutic value of test with clomifene in men with a Hypogonadizm
Author(s) -
Р. В. Роживанов,
Роживанов Роман Викторович,
Д Г Курбатов,
Курбатов Дмитрий Геннадьевич,
Nataliya Sergeevna Kravtsova,
Кравцова Наталия Сергеевна
Publication year - 2016
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl201662135-37
Subject(s) - clomifene , medicine , testosterone (patch) , predictive value , antiestrogen , test (biology) , gynecology , tamoxifen , ovulation , hormone , biology , paleontology , ovulation induction , cancer , breast cancer
Aim.In the real research test with an antiestrogen clomifene is offered for differential diagnostics of potential reversibility of a hypogonadism.Material and methods.After initial determination of levels of testosterone and LH, to 55 men with a hypogonadism clomifene citrate of 50 mg orally daily in the morning for 10 days was administrated. Levels of testosterone and LH repeatedly were defined on the 11th day.Results.The carried-out test with clomifene eliminated a hypogonadism at 85,5% of patients, thus the effect remained at 40%. The test was safe, at one of men of side effects it wasn’t noted. For patients with negative result of test (preservation of a hypogonadism) administration of preparations of testosterone was recommended. Conclusions. Test allows not only to differentiate reversibility of a hypogonadism, but also in some cases completely to eliminate it.