Differential and diagnostic, predictive and therapeutic value of test with clomifene in men with a Hypogonadizm

Aim.In the real research test with an antiestrogen clomifene is offered for differential diagnostics of potential reversibility of a hypogonadism.Material and methods.After initial determination of levels of testosterone and LH, to 55 men with a hypogonadism clomifene citrate of 50 mg orally daily in the morning for 10 days was administrated. Levels of testosterone and LH repeatedly were defined on the 11th day.Results.The carried-out test with clomifene eliminated a hypogonadism at 85,5% of patients, thus the effect remained at 40%. The test was safe, at one of men of side effects it wasn’t noted. For patients with negative result of test (preservation of a hypogonadism) administration of preparations of testosterone was recommended. Conclusions. Test allows not only to differentiate reversibility of a hypogonadism, but also in some cases completely to eliminate it.