Open AccessTreatment of pituitary dwarfism in children and teenagers in the Stavropol territory
Author(s) -
Leonid Yakovlevich Klimov,
Климов Леонид Яковлевич,
Roza Atanesyan,
Атанесян Роза Артуровна,
Tatyana A. Uglova,
Углова Татьяна Алексеевна,
Tatyana M. Vdovina,
Вдовина Татьяна Михайловна,
Viktoria Alexandrovna Kuryaninovna,
Курьянинова Виктория Александровна,
Marina Stoyan,
Стоян Марина Валерьевна,
Svetlana Dolbnya,
Долбня Светлана Викторовна,
Lilit Samvelovna Alaverdyan,
Алавердян Лилит Самвеловна,
Rafael Isaakovich Arakelyan,
Аракелян Рафаэль Исаакович,
Elena Semenovna Slavickaya,
Славицкая Елена Семёновна,
Elena Otarievna Demurcheva,
Демурчева Елена Оториевна,
Tatyana Boleslavovna Semenova,
Семёнова Татьяна Бореславовна
Publication year - 2016
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl201662110-15
Subject(s) - dwarfism , medicine , somatotropic cell , anthropometry , growth hormone , endocrinology , pediatrics , growth hormone deficiency , hormone , biology , biochemistry , gene
The article is devoted to the analysis of clinical and anthropometric indicators of 38 children and adolescents with pituitary dwarfism in the Stavropol region, receiving replacement therapy with recombinant growth hormone (rGH). The authors demonstrated a high growth stimulating efficacy of the rGR, as well as a positive impact on the level of blood cholesterol in children with somatotropic deficiency. Prognostic factors influencing the effectiveness of treatment were found (chronological age of initiation of therapy, baseline SDS of growth). In particular, it is shown that therapy with preparations of GH in children aged 8 to 10 years allows you to achieve a higher growth-stimulating effect in comparison with patients whose treatment is carried out at a later age. The study of the relationship between the initial deviation of the length of the body and the results of therapy in patients with growth hormone deficiency illustrates that a pronounced lag in growth is a predictive factor provides a more significant effect drugs rGR.