Open AccessAssociation of the CCR5 gene with type 1 diabetes mellitus
Author(s) -
О И Копылова,
Тамара Леонидовна Кураева,
Е Ю Лаврикова,
Е. В. Титович,
Alexey G. Nikitin,
Г Е Смирнова,
V А Peterkova,
И И Дедов,
В В Носиков
Publication year - 2013
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl20135923-6
Subject(s) - genotype , diabetes mellitus , type 2 diabetes mellitus , medicine , allele , allele frequency , polymorphism (computer science) , type 2 diabetes , population , endocrinology , gene , genetics , biology , environmental health
Aim of the study. To elucidate the association between the polymorphous marker A/del132 of the CCR5 gene with type 1 diabetes mellitus. Materials and methods. The study included 177 patients with type 1 diabetes mellitus (DM1) and 408 healthy subjects (ethnic Russians). CR5 alleles and genotypes were identified with the use of the real-time amplification technique. Results. It was shown that the CCR5 allele without 32 base pair deletion (allele A) predominated in both diabetic patients and diabetes-free subjects. The difference between their occurrence in the two groups was insignificant. At the same time, we documented a significant rise in the frequency of del132/del132 genotype in the diabetic patients compared with the healthy subjects (p=0.008). It is concluded that carriers of the CCR5-del32/del32 genotype in the Russian population of Moscow are at high risk of developing type 1 diabetes mellitus.