Open AccessA new principle of the treatment of type 2 diabetes mellitus by stimulation of glucosuria
Author(s) -
V. Stoičkov
Publication year - 2012
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl201258454-57
Subject(s) - medicine , stimulation , diabetes mellitus , urinary system , adverse effect , broad spectrum , type 2 diabetes mellitus , canagliflozin , pharmacology , endocrinology , chemistry , combinatorial chemistry
The results of clinical and experimental studies of a new group of medications are presented, with special emphasis laid on the inhibitors of sodium-glucose co-transporter SGLT2 employed for the treatment of type 2 diabetes mellitus. The mechanism of action of these inhibitors consists of the stimulation of glucosuria and the subsequent decrease of hyperglycemia. The new group of pharmaceutical products being considered is characterized by high therapeutic efficacy, safety, and the narrow spectrum of side effects. The most important adverse reactions are infectious lesions in the urinary tract and genital organs.