The role of specific chaperons in pathogenesis of obesity and related diseases | Zendy

О. В. Васюкова | Zendy; П. Л. Окороков | Zendy

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The role of specific chaperons in pathogenesis of obesity and related diseases

Author(s) -

О. В. Васюкова,

П. Л. Окороков

Publication year - 2012

Publication title -

problems of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.124

H-Index - 5

eISSN - 2308-1430

pISSN - 0375-9660

DOI - 10.14341/probl201258448-53

Subject(s) - inflammation , proinflammatory cytokine , endoplasmic reticulum , extracellular , pathogenesis , intracellular , obesity , diabetes mellitus , chemistry , microbiology and biotechnology , biochemistry , biology , endocrinology , immunology

Obesity, type 2 diabetes mellitus, and atherosclerosis are associated with the development of "metabolic" inflammation. The proinflammatory mechanisms in adipocytes and macrophages are initiated by both extracellular mediators (cytokines, saturated fatty acids) and intracellular processes (endoplasmic reticulum stress, excessive production of free radicals). An important role in the development of "metabolic" inflammation is played by protein transporters of fatty acids ("fatty acid-binding proteins").

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