Open AccessThe role of specific chaperons in pathogenesis of obesity and related diseases
Author(s) -
О. В. Васюкова,
П. Л. Окороков
Publication year - 2012
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl201258448-53
Subject(s) - inflammation , proinflammatory cytokine , endoplasmic reticulum , extracellular , pathogenesis , intracellular , obesity , diabetes mellitus , chemistry , microbiology and biotechnology , biochemistry , biology , endocrinology , immunology
Obesity, type 2 diabetes mellitus, and atherosclerosis are associated with the development of "metabolic" inflammation. The proinflammatory mechanisms in adipocytes and macrophages are initiated by both extracellular mediators (cytokines, saturated fatty acids) and intracellular processes (endoplasmic reticulum stress, excessive production of free radicals). An important role in the development of "metabolic" inflammation is played by protein transporters of fatty acids ("fatty acid-binding proteins").