Open AccessMetabolic and hemostatic characteristics of patients with type 2 diabetes mellitus differing in the severity of angiopathy
Author(s) -
Г. Г. Петрик,
С. А. Павлищук
Publication year - 2010
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl201056215-19
Subject(s) - medicine , angiopathy , diabetes mellitus , diabetic angiopathy , hemostasis , fibrinogen , partial thromboplastin time , nephropathy , type 2 diabetes mellitus , microalbuminuria , type 2 diabetes , microangiopathy , gastroenterology , platelet , albuminuria , von willebrand factor , endocrinology , disease
The objective of the present study was to identify risk factors of developing vascular disorders in patients at different stages of type 2 diabetes mellitus (DM2) by comprehensive analysis of metabolic parameters, hemograms, thrombocytic and plasma hemostasis. The study involved 75 patients (22 men and 53 women of mean age 57,3±9,7 years) having angiopathies of different severity. The data obtained confirmed the presence of risk factors of vascular pathology in different phases of DM2. All the examined patients including those without angiopathies in the early period of diabetes showed triglyceridemia, cholesterolemia, enhanced platelet aggregation activity, and shortened activated partial thromboplastin time. Patients with diabetic nephropathy at the stage of microalbuminuria and with non-proliferative retinopathy were distinct from the remaining ones in that they had significantly higher blood alpha-2 globulin and fibrinogen levels. Diabetic patients with micro- and macrovascular problems were characterized by marked dysproteinemia and abnormal platelet disaggregation.