Open AccessBrain GABA-receptor systems in functional thyroid disorders
Author(s) -
Feruza Khidoyatovna Inoyatova,
A K Tonkikh,
Gil'noza Turdalievna Yakubova,
Flora Inoyatova,
A K Tonkikh,
D T Yakubova
Publication year - 2009
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl200955528-30
Subject(s) - neuroscience , thyroid , receptor , medicine , biology , endocrinology
This experimental study was designed to evaluate effects of hypo- and hyperthyroidism on the density of 3H-muscimol and 3H-diazepam-binding sites in synaptic membranes of the rat brain. It was shown that density of both 3H-muscimol and 3H-diazepam-binding sites increases in animals with hypothyroidism and decreases in hyperthyroidism. This difference may account for the predominance of general inhibitory reaction in animals with hypothyroidism and general excitation in hyperthyroid rats.