Open AccessDynamics of prevalence of functional thyroid dysfunctions among pregnant women in Moscow from 1999 to 2008
Author(s) -
В. В. Фадеев,
S P Topalyan,
S. V. Lesnikova,
Г. А. Мельниченко,
В. В. Фадеев,
S P Topalyan,
S. V. Lesnikova,
G F Mel'nichenko
Publication year - 2009
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl200955514-19
Subject(s) - medicine , thyroid , dynamics (music) , physiology , obstetrics , endocrinology , psychology , pedagogy
The objective of this study was to study dynamics of prevalence of functional thyroid dysfunctions among pregnant women. The levels of TSH, free T4, and antithyroid peroxidase antibodies (ATP-AB) were measured in randomly selected women of different gestational age who applied to be registered in a maternity welfare centre in 1999-2003 (n = 215) and 2006-2008 (n = 325). The available data indicate that iodine consumption by the study populations increased during the above periods even if still remains subnormal. No statistically significant decrease in the occurrence of ATP-AB and hypothyroidism was recorded. Women carrying ATP-AB in the first and seconds trimesters of pregnancy had significantly higher TSH levels compared to those without ATP-AB. A change of diagnostic criteria for hypothyroidism (lowering the reference TSH threshold from 4.0 to 2.5 mU/l accounts for a several-fold rise (by a factor of 2-7) in the prevalence of hypothyroidism among pregnant women.