Open AccessThe antidepressant effects of α-lipoic acid and reamberin in murine alloxan diabetes
Author(s) -
Il'ya Anatol'evich Volchegorskiy,
Л. М. Рассохина,
Irina Yur'evna Miroshnichenko,
I. A. Volchegorsky,
Л. М. Рассохина,
I. Yu. Miroshnichenko
Publication year - 2009
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl200955420-24
Subject(s) - antidepressant , open field , alloxan , diabetes mellitus , endocrinology , lipoic acid , medicine , pharmacology , chemistry , biochemistry , hippocampus , antioxidant
The development of alloxan diabetes in mice is followed by a longer duration of despair behavior, homologous depression in man and a concomitant decrease in the activity of animals in the open field. The 2-week course of α-lipoic acid (α-LA) and reamberin in the doses equivalent to the human therapeutic range exerts an antidepressant activity, as appeared by a reduction in despair behavior and activation of sick mice in the open field. The antidepressant effect of 2-week use of α-LA and reamberin is associated with diminished hyperglycemia. Unlike α-LA, reamberin lowers the blood content of glucose in mice with alloxan diabetes, reduces their mortality, and corrects behavioral disorders in the open field even when relatively low doses are singly administered.