Open AccessThe intensity of lipid peroxidation processes, the activity of NADP-dependent dehydrogenases and proteases in rat brain with repeated administration of insulin
Author(s) -
П. К. Телушкин
Publication year - 1998
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl199844335-37
Subject(s) - lipid peroxidation , glutathione reductase , proteases , superoxide dismutase , oxidative stress , endocrinology , chemistry , medicine , biochemistry , insulin , glutathione , biology , enzyme , glutathione peroxidase
The rate of accumulation of malonic dialdehyde was increased, the activities of superoxide dismutase, NADP-dependent glucose- 6-phosphate, malate, isocitrate dehydrogenases and glutathione reductase decreased, and the levels of diene conjugates decreased in the hemispheres and brain stem of rats subjected to 7-9 hypoglycemic comas. The activities of neutral and acid proteases were increased in the stem structures. The detected changes indicate an oxidative stress developing in the nerve tissue after repeated hypoglycemic exposures. Such changes appear after glucose arrest of hypoglycemic coma and can be important in the pathogenesis of posthypoglycemic encephalopathy.