Open AccessThe dynamics of thyroid hormones in rats when modeling polycystic ovary syndrome
Author(s) -
С. Н. Смирнова,
М. Ф. Ромашова,
A. V. Antonichev,
В А Королев
Publication year - 1998
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl199844333-35
Subject(s) - polycystic ovary , endocrinology , medicine , triiodothyronine , hormone , testosterone (patch) , thyroid , biology , ovary , insulin , insulin resistance
The time course of triiodothyronine, thyroxine, and progesterone is followed up in albino rats with polycystic ovaries developing after postnatal androgenization of newborn females. Serum and plasma hormones were measured by competitive immunoassay based on intensified fluorescence. Serum and plasma T3 and T4 levels in rats with polycystic ovaries during the period corresponding to sexual maturation were higher than in normal animals. In adult rats T3 levels in the experimental and control animals leveled, but T4 content was decreased in androgen-treated animals. Progesterone level in health was notably higher than in animals with polycystic ovaries at all stages of postnatal ontogenesis.