Open AccessComparative evaluation of the inotropic effect of lipophilic and hydrophilic forms of 17P-estradiol and progesterone
Author(s) -
A. I. Matyushin,
A. N. Karachentsev,
S. A. Isaev,
A. Zh. Mambetova
Publication year - 1997
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl199743643-45
Subject(s) - contractility , inotrope , medicine , endocrinology , chemistry , atrium (architecture) , steroid , biology , hormone , atrial fibrillation
Changes in the contractility under the effect of lipophilic and hydrophilic 17^-estradiol and progesterone were studied on an isolated atrial auricula. The hydrophilic forms of female sex steroids possessed a higher cardiotropic activity than their lipophilic analogs. Lipophilic 17^-estradiol suppressed, whereas the hydrophilic form boosted the contractile function of the isolated rat atrium. Progesterone depressed cardiac contractility, no matter which forms were used.