Comparative evaluation of the inotropic effect of lipophilic and hydrophilic forms of 17P-estradiol and progesterone | Zendy

A. I. Matyushin | Zendy; A. N. Karachentsev | Zendy; S. A. Isaev | Zendy; A. Zh. Mambetova | Zendy

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Comparative evaluation of the inotropic effect of lipophilic and hydrophilic forms of 17P-estradiol and progesterone

Author(s) -

A. I. Matyushin,

A. N. Karachentsev,

S. A. Isaev,

A. Zh. Mambetova

Publication year - 1997

Publication title -

problems of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.124

H-Index - 5

eISSN - 2308-1430

pISSN - 0375-9660

DOI - 10.14341/probl199743643-45

Subject(s) - contractility , inotrope , medicine , endocrinology , chemistry , atrium (architecture) , steroid , biology , hormone , atrial fibrillation

Changes in the contractility under the effect of lipophilic and hydrophilic 17^-estradiol and progesterone were studied on an isolated atrial auricula. The hydrophilic forms of female sex steroids possessed a higher cardiotropic activity than their lipophilic analogs. Lipophilic 17^-estradiol suppressed, whereas the hydrophilic form boosted the contractile function of the isolated rat atrium. Progesterone depressed cardiac contractility, no matter which forms were used.

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