Open AccessThe effect of estrogen deficiency on rat ganglioside metabolism
Author(s) -
Tаlаt Sааtоv,
E. I. Isaev,
M. Zh. Ergashova,
O. Yu. Kukina,
Agureev An
Publication year - 1997
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl199743637-39
Subject(s) - endocrinology , medicine , estrogen , skeletal muscle , metabolism , ganglioside , lipid metabolism , chemistry , biochemistry
The effect of estrogen insufficiency on the formation of gangliosides from precursors is studied. Oophorectomy changes the production of gangliosides in the heart, skeletal muscles, fatty tissue, and pancreas. Estrogen insufficiency is paralleled by decrease of cardiac monosialogangliosides G^j and GM3> skeletal muscle disialogangliosides GDlb and GDla and monosialogangliosides Gmi end Gmj, fatty tissue disialoganglioside GDlb and monosialogangliosides G^] and GM3> and pancreatic monosialoganglioside GMI. The findings indicate that estrogens can contribute to regulation of ganglioside metabolism.