Open AccessHepoxylins - activators of ATP-dependent K + channels B cells of the pancreas are normal and in pathology
Author(s) -
В. Н. Бабичев,
Nicola Ignatiev,
М. И. Балаболкин,
К. K. Pivnitsky
Publication year - 1997
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl199743528-31
Subject(s) - exocytosis , electrophysiology , secretion , insulin , chemistry , medicine , endocrinology , pancreas , microbiology and biotechnology , biology
ATP-dependent channels of pancreatic ft-cells functionally attenuated by streptosotocin and their reaction to hepoxylin HxB3 are analyzed. Highly specific response of the above ionic channels to glucose and HxB3 hepoxylin was observed. Analysis of the time course of electrophysiological processes in the channels showed appreciable changes in the time of their closure, which resulted in a slower secretion of insulin starting from the moment of glucose and hepoxylin exposure and till the moment of exocytosis of insulin quantum. Under experimental conditions hepoxylin was a more potent inductor of secretion than glucose.