Open AccessHepatopulmonary syndrome: a rare manifestation of cirrhosis in patient with diencephalic obesity and nonalcoholic fatty liver disease after surgery for craniopharyngioma
Author(s) -
Н А Мазеркина,
A N Savateev,
Sergey Gorelyshev,
С. А. Маряшев,
S. A. Beregovskaya,
Alexander N. Konovalov
Publication year - 2021
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl12723
Subject(s) - craniopharyngioma , cirrhosis , medicine , nonalcoholic fatty liver disease , hypopituitarism , hepatopulmonary syndrome , surgery , liver disease , fatty liver , gastroenterology , disease , portal hypertension
We describe a 15-year girl, who developed panhypopituitarism and diencephalic obesity after surgical excision of craniopharyngioma, followed by nonalcoholic fatty liver disease and cirrhosis 5 years after surgery. Cirrhosis in this case manifested by hypoxia due to hepatopulmonary syndrome, and despite cure of craniopharyngioma by surgery and radiosurgery treatment and adequate hormonal substitution therapy patient died 9 years after surgery. Growth hormone substitutional therapy in patients with hypopituitarism, and steatohepatitis may decrease liver triglyceride accumulation and prevent end-stage liver disease.