Open AccessThyroid function of rats kept on increased iodine diet fed with drinking water
Author(s) -
V. G. Selyatitskaya,
N. A. Palchikova,
С. В. Одинцов
Publication year - 1994
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl12195
Subject(s) - endocrinology , medicine , iodine , thyroid , triiodothyronine , hormone , thyroid function , excretion , thyroglobulin , urine , corticosterone , chemistry , glucocorticoid , organic chemistry
Thyroid and adrenocortical function was examined in rats fed increasing quantities of iodine with drinking water. No noticeable deviations in thyroid hormone levels were found in the blood of experimental animals. Thyroid hormone levels in thyroid tissue were changing in the same direction in the animals kept on various iodine diets, these changes depending on experiment duration: an increase of thyroxine and more so, of triiodothyronine was observed in 50 days, and reduction thereof in 90 days. In rats fed the maximal iodine dose, 8000 mcg daily, the level of thyroglobulin in thyroid tissue decreased. Increased iodine consumption reduced the glucocorticoid function of the adrenals in experimental animals, this manifesting by reduction of corticosterone level in the adrenals, blood plasma, and reduction of non-metabolized hormone excretion with the urine.