Open AccessTime course of the cellular and humoral immunity parameters in patients with type I diabetes mellitus
Author(s) -
V. V. Potyomkin,
Tatiana Vasil'evikonova,
S. V. Brykova
Publication year - 1994
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl12179
Subject(s) - medicine , diabetes mellitus , disease , antibody , antigen , human leukocyte antigen , immunology , type 2 diabetes mellitus , immune system , lymphocyte , islet , autoantibody , cytotoxic t cell , endocrinology , biology , in vitro , biochemistry
Fifty-two patients with type I diabetes mellitus were examined. The patients were divided into 4 groups with various duration of the disease: group 1 included patients with the newly diagnosed disease, group 2 those with disease standing of 1 to 5 years, group 3 were patients suffering from diabetes for 6 to 10 years, and group 4 were diabetics for 10 years and more. The parameters examined were antibodies to surface antigens of islet cells, absolute and relative counts of T and В lymphocytes in the peripheral blood, counts of T-helpers and T-suppressors and cytotoxic cells and their ratios, counts of natural killers, DR (+) and IgG (+) cells, and basal C- peptide level. The results showed a correlation between autoantibodies to surface antigens of islet cells and the count of В lymphocytes, an inversion of T lymphocyte subpopulations, with the helper/sup- pressor index increased at the initial stages of the disease and decreasing with the disease progress.