Ya. I. Tomashevsky, A. Ya. Tomashevskaya. Foundations of Prophylactic Diabetology

The peer-reviewed monograph summarizes the results of many years of research by the head of the endocrinology department of the Lviv Medical Institute prof. Ya. I. Tomashevsky and his staff dedicated to the early diagnosis of diabetes mellitus (DM) using pyruvaturic, pyruvatemic and pyruvate dehydrogenase tests. The significance of these studies, both scientifically and in practical terms, is undeniable. Very important in the prevention of diabetes mellitus, especially insulin-dependent diabetes, is the ability to identify individuals genetically predisposed to diabetes with these methods. Under conditions of low-intensity Lviv radioactivity, such a predisposition in the general population was 28.77%, which is 3.77% higher compared to the literature. The authors discovered pyruvic diabetes syndrome, the frequency of which in the general population is 8.90% (the compensation phase is 6.16%, the decompensation phase is 2.74%).The monograph consists of a brief introduction and 7 sections (chapters), the literary index contains 124 sources. A presentation of the methodology for conducting the above tests is preceded by Section 2, in which the authors evaluate the role of the pyruvate dehydrogenase system of mitochondria and the Measles cycle in the mechanism of regulation of carbohydrate metabolism.A relatively simple biochemical method for the determination of pyruvate in urine and blood under conditions of a carbohydrate load provides very valuable information that allows for early diagnosis of diabetes. The authors also identify options for the borderline states of glucose tolerance: insufficiency of the early phase of insulin secretion, pyruvate dehydrogenase hyper- and hypotolerance, contra -insulin deficiency (relative hyperinsulinism), etc.