Open AccessThe function of the hypothalamothyroid system after cainate injection to the ventrolateral portion of medulla obtongara
Author(s) -
T. V. Dudina,
A. I. Yeolkina,
T. S. Kandybo,
O. A. Azev,
Vladimir A. Kulchitsky
Publication year - 1994
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl12173
Subject(s) - medulla oblongata , endocrinology , medicine , anatomy , chemistry , central nervous system , biology
Contribution of the bulbar structures to mechanisms of realization of the hypothalamothyroid system feedback was studied in experiments on 73 adult male Wistar rats. Histologically confirmed unilateral destruction of neurones in the caudal part of medulla oblongata ventral portions after injection of 0.65 pg of cainate as soon as 30 min after injection was paralleled by a trend to increase of the blood serum levels of triiodothyronine and thyroxin-binding globulin, this increase attaining reliable values by day 7 after destruction, when the effects of operation stress levelled. During the same period wc observed activation of glucocorticoid-dependent choline-, serotonin-, and noradrenergic- processes in the mediobasal zone of the hypothalamus, this indicating the presence of functional relationships of medulla oblongata ventral portions with the hypothalamothyroid system realized by disinhibition of this system during destruction of neurones in the caudal part of the ventral portion of medulla oblongata.