Open AccessEffects of plasmapheresis and immunocorrecting therapy on T-immunity of pa¬tients with autoimmune thyroiditis
Author(s) -
А. А. Калинин,
Д. С. Рафибеков,
Ye. Ye. Potemkina,
Н. В. Пешева,
В. Н. Шабалин
Publication year - 1994
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl12136
Subject(s) - medicine , plasmapheresis , immunity , immunology , thyroid function , thyroid , autoimmune thyroiditis , thyroiditis , gastroenterology , immune system , antibody
T-cellular immunity was studied in 104 patients with autoimmune thyroiditis to assess the function of the thyroid and treatment method. A reliable reduction of the activity of T-lymphocyte receptor system, lymphopoiesis activation, and their relationship with the thyroid status were revealed. Plasmapheresis as monotherapy was used in 22 patients. It brought about a short-term positive effect, this necessitating search for other methods of' immunorehabilitation. In 82 patients it was supplemented with immunocorrecting therapy (thymalin) and in 49 with hypothyrosis with substitution therapy (L-thyroxine, thyroidin). Combined therapy helped attain a stable clinical and immunological effect. Subpopulation composition of T-lymphocytes recovered, their functional activity normalized (follow-up period 1 year).