Study of human thyroglobulin gene polymorphism | Zendy

Д. А. Кадырова | Zendy; Б. А. Атаханова | Zendy; М. Л. Рахимова | Zendy; Г. Д. Умарова | Zendy; Turakulov IaKh | Zendy

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Study of human thyroglobulin gene polymorphism

Author(s) -

Д. А. Кадырова,

Б. А. Атаханова,

М. Л. Рахимова,

Г. Д. Умарова,

Turakulov IaKh

Publication year - 1996

Publication title -

problems of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.124

H-Index - 5

eISSN - 2308-1430

pISSN - 0375-9660

DOI - 10.14341/probl12089

Subject(s) - restriction fragment length polymorphism , genetics , gene , polymorphism (computer science) , ecorv , restriction enzyme , biology , thyroglobulin , population , microbiology and biotechnology , genotype , thyroid , medicine , environmental health

The main goal of this work was to conduct a population genetic analysis of RFLP detected in the TG gene and to develop a system of molecular genetic studies of hereditary thyroid diseases associated with polynucleotide rearrangements in the structure of TG. A population genetic analysis of RFLP detected in the TG gene was carried out. When splitting blood samples of healthy Tashkent residents with EcoRV and Taql restriction enzymes, 2 pairs of alternative variants of normal RFLP were detected - 13.8 or 8.5 and 5.8 or 6.2 bp respectively. In order to detect RFLP in the TG gene for congenital hypothyroidism, DNA samples from 2 families (mother, father, daughter) with a clinical diagnosis of congenital hypothyroidism were analyzed and the same variants of RFLP found in healthy individuals.

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