Open AccessInsulin content and arterial pressure in obese women
Author(s) -
M. Ginzburg,
M. Ginzburg,
Г. С. Козупица,
Г. С. Козупица,
Oleg Sergeyev,
О. В. Сергеев
Publication year - 1996
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl12067
Subject(s) - insulin resistance , obesity , medicine , endocrinology , basal (medicine) , pathogenesis , hyperinsulinism , blood pressure , insulin , hyperinsulinemia , diabetes mellitus
The pathogenesis of hypertension developing in obesity is still to be studied. Hyperinsulinism and insulin resistance are believed to contribute to it. A relationship between the levels of basal and glucose-stimulated immunoreactive insulin (IRI) and arterial pressure (AP) has been studied in 36 women aged 18 to 37 suffering from obesity of the first-fourth degrees. Basal IRI level was appreciably increased and directly correlating with systolic and diastolic AP, but not related to body weight excess. AP directly depended on the degree of obesity and disease standing, but not on patient's age. These data permit us to conclude that insulin contributes to the pathogenesis of hypertension in obese women, but further studies are needed to elucidate the type and mechanisms of this contribution.