Open AccessAdrenal steroids in the blood and urine and the immune status of women with age-associated disorders of glucose tolerance
Author(s) -
В. И. Один,
Т. Е. Порошина,
Е. В. Цырлина,
Lev M. Berstein
Publication year - 1996
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl12066
Subject(s) - endocrinology , medicine , hyperinsulinemia , immune system , dehydroepiandrosterone , insulin , androgen , urine , immunity , pokeweed mitogen , urinary system , biology , immunology , insulin resistance , hormone , peripheral blood mononuclear cell , in vitro , biochemistry
Dehydroepiandrosterone (DHA), hydrocortisone, and insulin are naturally occurring substances influencing the immune functions. The present paper is devoted to their combined effects on the mitogen-stimulated proliferation of lymphocytes (MSPL) with phytohemagglutinin-M (PHA-M) and Pokeweed mitogen used as stimulants. A positive correlation between blood insulin and urinary DHA levels (r=0.534; p0.05) has been revealed. The level of DHA secretion was in a negative correlation with the values of MSPL stimulated by PHA-M (r=-0.651; p0.01). Hence, age-associated hyperinsulinemia may be regarded as an important regulator of both, adrenal androgen production and the cellular immunity status.