Open AccessEnzymuria in diabetics with type ii condition and disordered purine metabolism
Author(s) -
Z. O. Gheorgadze,
М. И. Балаболкин,
G. G. Mamayeva,
L. I. Lyudina,
B. P. Mischenko
Publication year - 1996
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl12065
Subject(s) - medicine , endocrinology , hyperuricosuria , diabetes mellitus , purine , purine metabolism , urine , chemistry , enzyme , biochemistry , hypercalciuria
The authors compare enzymuria occurring in disorders of purine metabolism in patients with types I and II diabetes. Urinary enzymes (alkaline phosphatase, lactate dehydrogenase, N-acetyl-b-D-glucosaminidase, alanine aminopeptidase, cholinesterase, and b-galactosidase) were measured in 25 patients with noninsulin-dependent (NIDDM) and insulin-dependent diabetes mellitus (IDDM) with different disorders of purine metabolism (hyperuricemia and hyperuricosuria) and in 27 normal controls. The study revealed the syndrome of enzymatic insufficiency and syndrome of increased glomerular permeability (expressed increase of cholinesterase level in the urine) in patients with NIDDM; the latter syndrome was expressed similarly in patients with both NIDDM and IDDM. This syndrome was particularly severe in patients with IDDM complicated by diabetic nephropathy and disordered purine metabolism.