Open AccessChorionic gonadotropin test in the diagnosis of hermaphroditism variants caused by congenital disorders of testosterone biosynthesis
Author(s) -
Л. Н. Самсонова
Publication year - 1996
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl12039
Subject(s) - male pseudohermaphroditism , true hermaphroditism , testosterone (patch) , basal (medicine) , human chorionic gonadotropin , gonadotropin , disorders of sex development , biology , medicine , endocrinology , physiology , hormone , genetics , karyotype , gene , insulin , chromosome
The study is devoted to search for the optimal modification of chorionic gonadotropin test which permits timely assessment of the function of gonads and, hence, diagnose the variants of hermaphroditism caused by disordered biosynthesis of testosterone. Two modifications of the test: three-day and two-week with measurements of basal and stimulated testosterone levels in the serum were used in 18 patients aged 10 months to 10 years. Both modifications were diagnostically valuable in assessing the function of the gonads in patients with male pseudohermaphroditism. However, the three-day test with its 83% sensitivity may be used only as a screening method in the diagnosis of the above condition.