Open AccessThe effect of new long-acting testosterone bucyclate ester on the spermatogenesis and endocrine function of steroid-secreting glands in male Papio hamadryas
Author(s) -
Н. П. Гончаров,
G. V. Katsiya,
Vladimir Y. Butnev,
V. M. Gorlushkin
Publication year - 1996
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl12028
Subject(s) - testosterone (patch) , endocrinology , medicine , spermatogenesis , androgen , endocrine system , hormone , dehydroepiandrosterone , steroid , chemistry , biology
Effects of two (at 3 month interval) intramuscular injections of testosterone bucyclate (ТВ) in doses of 4 and 8 mg/kg b. w. were studied in adult male Papio hamadryas. Both ТВ doses suppressed spermatogenesis, but this effect abated with dose increase. Azoospermia was observed in 33% ejaculate samples after ТВ in a dose of 4 mg/kg, whereas after injection of 8 mg/kg it was found in only 6% samples. Moreover, the level of peripheral testosterone depends on ТВ dose as well. It reduces by half after injection of a lower dose and surpasses the control values by 20 to 120% after injection of 8 mg/kg. Time course of LH after injection of the androgen in both doses was characterized by a phase pattern: during the first phase (0 to 16 weeks) the levels of hormone varied, and a trend to reduction could be traced; during the second phase (weeks 16-24) the concentration of the hormone sharply increased and thus remained till the end of experiment. Prolonged exposure to long-acting ТВ may inhibit the secretion of adrenal androgen dehydroepiandrosterone and precursor of the ∆5-pathway of steroid synthesis 17-Oxypregnelone.