Open AccessInsulin and adrenalin effects on the activity and concentration of glutathione metabolizing enzymes in rat organs
Author(s) -
Л. С. Колесниченко,
V. I. Kulinsky,
M. V. Yas'ko,
Г. А. Пенсионерова,
Yu. V. Grudinina
Publication year - 1994
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl12015
Subject(s) - glutathione , glutathione reductase , endocrinology , medicine , insulin , glutathione peroxidase , enzyme , spleen , gpx3 , chemistry , biology , biochemistry
Adrenaline activates glutathione peroxidase in the heart, liver, and kidneys and glutathione transferase in the heart and liver, inhibits gamma-glutamyl transferase in the kidneys, and has no effect on glutathione reductase; no changes in the brain detected. Insulin does not influence glutathione reductase either, nor does it induce any changes in the heart, liver, and bone marrow, but it alters (as a rule reduces) in a number of cases the activities of many glutathione metabolism enzymes and reduces glutathione concentration in the brain, kidneys, and spleen both an hour and 24 h after injection. The detected changes do not conform to universally acknowledged classification of the organs by insulin sensitivity and do not correlate with hypoglycemia.