Open AccessProlactinaldosterone humoral system in patients with postoperative hypothyrosis and arterial hypertension
Author(s) -
Ustinova Se,
Mychka Vb,
Gerasimov Ga
Publication year - 1994
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl12007
Subject(s) - dopaminergic , medicine , plasma renin activity , endocrinology , blood pressure , aldosterone , hormone , prolactin , essential hypertension , renin–angiotensin system , agonist , pathophysiology of hypertension , dopamine , receptor
Clarification of the possible pathogenetic relationship of hypothyroidism and arterial hypertension (AH) is relevant for the clinic in connection with two well-known observations: normalization of blood pressure in such patients on the background of thyroid hormone replacement therapy and the hypotensive effect of thyroid drugs in some patients with essential hypertension. AH, according to various authors, is detected in 10-50% of patients with hypothyroidism.
The literature discusses two possible mechanisms for the formation of hypertension in hypothyroidism: the presence of a volume factor and increased sympathetic activity. With the greatest constancy in such patients suppression of renin activity is detected, in some cases, an increased content of norepinephrine in the blood plasma and increased excretion of it in the urine are determined. Hyperprolactinemia, often observed in hypothyroidism, hyperaldosteronemia, detected in some cases in patients with hypothyroidism and hypertension, are of particular interest in connection with the known data on the inhibitory factor common to both hormones - the dopaminergic activity of the hypothalamus.
Given the general dopaminergic mechanism of regulation of prolactin (PRL) and aldosterone (A), it is logical to assume that the combined hyperproduction of both hormones may be due to a deficiency of dopaminergic activity.
According to our own preliminary observations, hypertension, which has developed or worsened due to postoperative hypothyroidism, is associated with low renin activity, hyperprolactinemia and hyperaldosteronemia, corrected by the dopaminergic receptor agonist - parlodel.
The aim of this work was to study the relationship in the PRL - A system in patients with hypertension that developed after resection of the thyroid gland.