Classification of growth hormone idiopathic insufficiency: Clinical features and efficacy of therapy with growth hormone

In 3,226 patients with idiopathic growth hormone (GH) deficiency included in the KIGS study, a comparative analysis of epidemiological factors and the effectiveness of treatment with recombinant GH depending on the presence or absence of birth trauma was performed. The relative frequency of gluteal presentation, instrumental AIDS in childbirth, reduced Apgar score, neonatal hypoglycemia and occurrence of microfallos was higher in the group with birth trauma, which was manifested later by more severe hypopituitarism and earlier manifestations of the disease. Both groups had almost the same reaction to GH therapy. A similar study was conducted in a group of children with GH deficiency in combination with empty Turkish saddle syndrome, septooptic dysplasia, cleft palate, neurosecretory dysfunction and secretion of biologically inactive GH. The comparative analysis was carried out with a group of children with idiopathic insufficiency of GH. Despite the differences in the clinical picture between the groups, the effectiveness of treatment of GH was the same. The study confirms the concept of multifactorial etiology of idiopathic gr insufficiency. Comparison with other groups of congenital insufficiency of GH indicates that complications in the perinatal period may occur secondary to hypopituitarism.