Effect of a-tocopherol on the development of diabetic angiopathy, platelet aggregation, and prostacyclin-thromboxan system of rats with streptozotocin-induced diabetes | Zendy

G. F. Zadkova | Zendy; T. Yu. Avakyan | Zendy; Kh M Markov | Zendy

Open Access

Effect of a-tocopherol on the development of diabetic angiopathy, platelet aggregation, and prostacyclin-thromboxan system of rats with streptozotocin-induced diabetes

Author(s) -

G. F. Zadkova,

T. Yu. Avakyan,

Kh M Markov

Publication year - 2019

Publication title -

problems of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.124

H-Index - 5

eISSN - 2308-1430

pISSN - 0375-9660

DOI - 10.14341/probl11988

Subject(s) - prostacyclin , platelet , streptozotocin , diabetes mellitus , medicine , endocrinology , vitamin e , arachidonic acid , angiopathy , microangiopathy , tocopherol , diabetic angiopathy , thromboxane , chemistry , antioxidant , biochemistry , enzyme

Under study were effects of intravenous infusions of a new emulsion, -tocopherol, on the development of diabetic microangiopathy, platelet -tocopherol level, ADP-induced platelet aggregation level, exogenic (from 14C-arachidonic acid) thromboxan (TxA2) biosynthesis in suspension of washed platelets and of prostacyclin (Pgb) one in isolated aortic rings of rats with streptozotocin-induced diabetes. Six-week injections of -tocopherol in a dose 100 mg/100 g b. w. with 48 h intervals immediately after development of streptozotocin-induced diabetes prevented the development of diabetic angiopathy but did not normalize platelet functional activity and Pgl2/TxA2 balance in vessels and platelets. Similar injections of -tocopherol in the presence of developed angiopathy resulted in its regressive development and normalization of the before-said prostanoid balance and platelet characteristics.

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