Open AccessEffect of a-tocopherol on the development of diabetic angiopathy, platelet aggregation, and prostacyclin-thromboxan system of rats with streptozotocin-induced diabetes
Author(s) -
G. F. Zadkova,
T. Yu. Avakyan,
Kh M Markov
Publication year - 2020
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11988
Subject(s) - prostacyclin , platelet , streptozotocin , diabetes mellitus , medicine , endocrinology , vitamin e , arachidonic acid , angiopathy , microangiopathy , tocopherol , diabetic angiopathy , thromboxane , chemistry , antioxidant , biochemistry , enzyme
Under study were effects of intravenous infusions of a new emulsion, -tocopherol, on the development of diabetic microangiopathy, platelet -tocopherol level, ADP-induced platelet aggregation level, exogenic (from 14C-arachidonic acid) thromboxan (TxA2) biosynthesis in suspension of washed platelets and of prostacyclin (Pgb) one in isolated aortic rings of rats with streptozotocin-induced diabetes. Six-week injections of -tocopherol in a dose 100 mg/100 g b. w. with 48 h intervals immediately after development of streptozotocin-induced diabetes prevented the development of diabetic angiopathy but did not normalize platelet functional activity and Pgl2/TxA2 balance in vessels and platelets. Similar injections of -tocopherol in the presence of developed angiopathy resulted in its regressive development and normalization of the before-said prostanoid balance and platelet characteristics.