Open AccessAtherogenic characteristics of oral sugar-reducing sulfonylurea derivatives
Author(s) -
M. A. Maxumova,
И.А. Собенин,
М. И. Балаболкин,
Alexander N. Orekhov
Publication year - 1994
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11986
Subject(s) - sulfonylurea , in vivo , blood sugar , pharmacology , chemistry , macrophage , in vitro , endocrinology , medicine , diabetes mellitus , biochemistry , biology , microbiology and biotechnology
The authors have examined the effects of sulfonylurea drugs glybenclamide and glypizide and of their analogs manilil and minidiab on cholesterol levels in murine peritoneal macrophages. Both glybenclamide and glypizide had a direct atherogenic effect on cultured murine peritoneal macrophages. A similar effect was observed in vivo: blood sera of diabetics after a single intake of 5 mg of manilil or minidiab increased the atherogenic potential of cultured murine peritoneal macrophages.