Activities of the anterior hypothalamus neurosecretory nuclear enzymes in exposure to organophosphorus compounds

Under study were activities of glycolysis enzymes: LDH, Crebs cycle SDH, those of electron transport system NAD and NADP-diaphorase, and of the hydrolytic enzymes, acid and alkaline phosphatases in the hypothalamus, as were morphofunctional shifts in these enzymes activities in poisoning with organophosphorus compounds. The experiments were carried out in 72 white male outbread rats weighing 180-200 g, that were administered PHOS antio (an organophosphorus compound) in a daily dose of 0.1 LD50 for 30 days. Early dates of poisoning were associated with an essential rise of the redox enzymes and a lowering of the hydrolytic enzymes levels, this being parallelled by morphologic signs of activation of the neurosecretory cells. Later high levels of neurosecretory material in the neurosecretory nuclei and reduced counts of neurosecretory cells were coupled with almost all the enzymes activities lowering. This permits a conclusion that changed activities of the enzymic systems may be one of the pathogenetic mechanisms and possible causes of neurosecretory cell dysfunction in pesticide poisonings