Open AccessEffect of long-acting gestagen levonorgestrel butanate on the spermatogenesis and endocrine function of the adrenals and gonads of papio hamadrias
Author(s) -
Н. П. Гончаров,
G. V. Katsiya,
Vladimir Y. Butnev,
V. M. Gorlushkin
Publication year - 1996
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11922
Subject(s) - levonorgestrel , endocrinology , medicine , testosterone (patch) , endocrine system , spermatogenesis , pregnenolone , hormone , population , steroid , research methodology , environmental health , family planning
Tlie efficacy of levonorgestrel butanate in doses 1, 2, 4, and 8 mg/kg in spermatogenesis suppression was studied in adult male Papio hamadrias. The drug was injected intramuscularly twice with 3 month interval. All gestagen doses had an inhibitory effect of spermatogenesis, this effect increasing with the dosage build-up. None of the animals developed azoospermia, which was due to incomplete suppression of the pituitary gonadotropic function and of testosterone secretion. Hormonal concentration in the peripheral blood was 55-60% reduced in response to the minimal dose and 60-80% reduced in response to the maximal dose. Injection of long-acting gestagen did not influence the secretion of adrenocortical hormones hydrocortisone, dehydroepiandrosterone, and pregnenolone.