The course of sexual maturation and specific features of the clinical status were retrospectively studied in 65 women aged 17 to 39 with functional variants of androgyny in order to detect the earliest symptoms of nontumorous androgyny which debuts, as a rule, during the pubertal period. The androgynous syndrome was combined with menstrual dysfunction in 56 patients and coursed as idiopathic hirsutism (with regular biphasic cycle) in 9. Twenty-three (41%) patients of those with menstrual dysfunction, but none of those with the normal cycle, had a history of inverted puberty which started by isolated pubarche. In contrast to patients with normal puberty, inverted puberty was associated with earlier pubarche, late thelarche, and similar terms of menarche, the duration of the premenarche androgenization being prolonged almost live-fold (2.8 0.6 years in patients with inverted puberty vs. 0.6 + 0.1 years in the rest, p0.001). Despite an earlier cessation of growth in inverted puberty, the final height was the same, no matter what the type of puberty. The characteristics of hirsutism were likewise the same, but menstrual dysfunction in patients with inverted puberty was reliably more incident, started earlier, and ran a more grave course (almost always with chronic anovulation). Pubarche was preterm (before the age of 8 years) in 7 patients with inverted puberty and delayed in 16, no differences of any kind being detected between the two groups. A concept on the pathologic type of inverted puberty has been formulated for the first time. Despite the period of its onset, isolated pubarche leads to prolonged androgenization of gonadostat to menarche, this involving a high risk of formation of still more grave nosologic variants of the androgynous syndrome complicated by fertility disorders.